EDUCATIONAL TRAINING / SHORT COURSES
Sunday, July 8, 2007

Two one-day short courses are available July 8, the Sunday preceding the meeting. The special rate is $200 per short course (50% off for academics and students).  Sign up for the short course of your interest as you register.

SHORT COURSE # 1
8:30AM - 4:00PM
CHIRAL CHROMATOGRAPHY:  ANALYTICAL & PREPARATIVE

Morning - Analytical Chiral Chromatography

ENANTIOMERIC SEPARATIONS
Instructor: Daniel W. Armstrong, University of Texas at Arlington, Arlington, TX, USA

This introductory short course is designed for researchers faced with separation or analysis of enantiomeric compounds. The goal of the course is to familiarize the participants with the best available options when confronted with the need for chiral separations. The first part of the material to be covered will include a review of the terminology of chirality and a brief overview of the theory behind enantiomeric separations. In addition, new products and techniques will be discussed. Participants should have a basic knowledge of chromatography and have previous experience with routine HPLC (reverse phase and normal phase), GC and CE. Topics include: History, Background and Nomenclature; Summary of LC Techniques; Chiroptical Detection and SFC Enantiomeric Analysis; Gas Chromatographic Separation of Enantiomers; and Discussion/Questions.

Afternoon - Preparative Chiral Chromatography

ADVANCES IN THE FIELD OF PREPARATIVE SEPARATION OF STEREOISOMERS
Instructor: Eric Francotte, NOVARTIS Institutes for BioMedical Research, Discovery Technologies, Basel, Switzerland

The significance of preparative enantioselective chromatography is definitely gaining increasing recognition as a powerful alternative of supplying the pure enantiomers of bioactive compounds. In particular, the concomitant introduction of both efficient chiral stationary phases and efficient separation techniques offers new possibilities which were not conceivable some years ago in the field of chromatographic separations. Recent progresses in the field of preparative chiral stationary phases will be discussed. The different approaches for method development as well as the preparative techniques which are applied in the pharmaceutical industry, including batch chromatography, simulated moving-bed (SMB) and supercritical fluid chromatography (SFC), will be presented. The usefulness of enantioselective chromatography as a valuable approach to separate optical isomers on a preparative and even production scale will be also illustrated with various practical applications. 

SHORT COURSE # 2
8:30AM - 4:00PM
SPECTROSCOPIC METHODS FOR STUDYING CHIRALITY

Morning - NMR

NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY FOR DETERMINING MOLECULAR STEREOCHEMISTRY AND ENANTIOMERIC PURITY
Instructor: Thomas Wenzel, Bates College, Lewiston, ME, USA

NMR spectroscopy is one of the most common methods used for the analysis of stereochemistry and the determination of enantiomeric purity. Discrimination between a pair of enantiomers is achieved by suitable coupling to an optically pure chiral reagent. Reagents used for chiral analysis in NMR spectroscopy are grouped into general categories of chiral derivatizing agents, chiral solvating agents, metal complexes, and liquid crystals. Common examples of reagents from these different categories will be described. The classes of compounds for which they are effective will be discussed. The assignment of absolute stereochemistry is possible if the reagent produces predictable and characteristic shifts in the NMR spectra of the enantiomers. Alternatively, empirical trends in the shifts are noted for certain classes of compounds with specific chiral reagents. The ability to use certain reagents for the assignment of absolute stereochemistry and/or determination of enantiomeric purity will be discussed. Chiral reagents that are commercially available or readily prepared from commercially available starting materials will be emphasized. 

Afternoon - Chiroptical Spectroscopy

CHIROPTICAL SPECTROSCOPIC METHODS FOR DETERMINING MOLECULAR STEREOCHEMISTRY AND ENANTIOMERIC PURITY
Instructor: Prasad Polavarapu, Vanderbilt University, Nashville, TN, USA

Revolutionary developments have taken place recently to facilitate the analysis of chiral molecules using chiroptical spectroscopic methods. Chiral analyses include determination of (a) absolute configuration at the chiral centers, (b) predominant conformations of chiral molecules and (c) enantiomeric purity. Due to the recent developments, chiroptical spectroscopic methods have become definitive methods for deriving the absolute configuration and predominant conformations. Four chiroptical spectroscopic methods that have become popular in recent years for obtaining this information are: Vibrational circular dichroism (VCD), Vibrational Raman optical activity (VROA), Electronic circular dichroims (ECD) and Optical rotatory dispersion (ORD). These methods will be discussed in two groups: VCD and VROA in the one part; ECD and ORD in the other part. For each of these methods the experimental methods for measurements will be discussed first. Then the theoretical methods for analyzing the experimental data will be discussed. The availability of commercial instruments for experimental measurements and commercial computer programs for theoretical predictions makes it possible now for these methods to be easily implemented in both the industrial and academic laboratories. Examples illustrating the applications of these methods and pertinent literature to help the participants adopt these methods will be provided.

Sign up for the short course of your interest as you register.

The Chirality Symposium reserves the right, without notice, to modify the short course material or schedules, as well as to amend the roster of short course presenters.